Techniques of analyses

MECOS-C2 system can be used for different types of biospecimen analyses, as investigational as special medical standards restricted.

Hardware&software MECOS-C2 system can be used for natural specimen analyses.

MECOS-C2 software can be used without MECOS-C2 equipment for virtual slides analyses. Only computer is needed for this type virtual technique. The virtual slides for MECOS-C2 analyses can be produced by different types of automated scanners.  MECOS-C2 programs can make cloud analyses if Internet resource MECOS-Virt is used for virtual slides access.

Below ^м index denotes techniques for medical purpose, ^I index denotes techniques of investigational purpose only.

Techniques for hematology

Techniques for helminth, urine sediment, spermatozoa

Multipurpose techniques

Techniques for hematology

Common properties

Visual control by a doctor of automated cell sorting (galleries on a computer monitor) makes possible  to correct quickly galleries compositions with sorting exactness increase up to 100%.

Compact viewing of cells in galleries increases pathological morphology detection. Analyses norm diapason depending of patient age is tuned automatically.

Statistics gathering for local norm region definition is available. 

Analysis results in standard form can be printed and fixed in database.

Database viewing allows to realize retrospective quality control.

The programs realize automated quality control of blood smear, using measurements of erythrocytes staining and layer thinness in sample gathering region.

Complete quality control of automated functions including visualization of smear screening trajectories and cell detection is available. 

A specimen digital model in form of virtual slide or cell sample galleries for staff teaching, external quality control, telemedicine are available.

Smear preparation by spatula, by centrifuge or by automated devices are possible. 

The ERYTHROCYTE ANALYSIS (MECOS-ERA^м) program for complete set with manual or motorized microscope performs dialogue microscopy of stained blood smear.

The BLOOD SMEAR ANALYSIS (MECOS-BSA^м) program for motorized complete set performs automatic microscopy of a stained blood smear. BSA scans smear by adaptable path and forms samples of leukocytes and erythrocytes of a given volumes. It makes a quantitative evaluation of anysocytosis and poikilocytosis, builds a Price-Jones graph, distribution of the hemoglobin quantity within the erythrocytes, distribution of erythrocytes by the shape, the 8 types formula of the pathological erythrocytes (schizocytes, megalocytes, echinocytes, stomatocytes, elliptocytes, teardrop cells, target cells, bite cells), erythrocyte ellipse coefficient. BSA makes 12 types presorting of leukocytes (segmented neutrophyles, lymphocytes, monocytes, eosinophyles, basophyles, band neutrophyles, blast cells, myelocytes, promyelocytes, metamyelocytes, plasmocytes, atypical lymph0cytes). Total presorting of MECOS-BSA is diff 12+8=20. Under 5% of relocations by a doctor of normal type leukocytes between  galleries usually needed with simply pressing a key. For more details see:

MECOS-C2 introduces quality standard of blood smear analyses

The HEMO ANALYSIS (MECOS-HEMO^I) program for motorized complete set integrates tools of MECOS-BSA and MECOS-FDMM, performs large (up to 5000 cells) all types leukocyte sample gathering or given type leukocyte sample gathering. Lymphocytogram, monocytogram, neutrophilogram (distributions of square, nucleus/cytoplasm ratio, and other morphological parameters) can be calculated.

The RETICULOCYTE ANALYSIS (MECOS-RETA^м) program for complete set with manual or motorized microscope counts concentration and distribution of reticulocytes in blood smear. If motorized, the technique inputs needed number of field of view in thin part of smear and reticulocyte recognition is performed at multiple focus positions. Automatically detected reticulocytes and erythrocytes are marked. Indexes of Reticulocyte Production (RPI) and Immature Reticulocyte Fraction (IRF ) are calculated.

The PLATELET ANALYSIS (MECOS-PLA^м) program for complete set with manual or motorized microscope is analogue of MECOS-RETA and is intended for platelet concentration and distribution (square) analysis. Automatically detected platelets and erythrocytes are marked.

The MYELOGRAM FORMING (MECOS-MYF^м) program for complete set with manual or motorized microscope provides with special menus and blanks of standard myelogram forming. The program has embedded marrow cells atlas.

The FLOW HEMOANALYZER INTEGRATION (MECOS-FHI^м) program  allows to integrate data of MECOS-BSA and laboratory flow hemoanalyzer.

Programs for helminth, urine sediment, spermatozoa, bacterial clumps analyses

The HELMINTH AND PROTOZOA ANALYSIS (MECOS-HPA^м) program for complete set with manual or motorized microscope offers menus and blanks of standard helminth and protozoa analysis. The program has embedded helminth and protozoa atlas.

The HELMINTH DETECTION (MECOS-HPD^м) program for motorized complete set performs automatic screening of a water, excrement or washout specimen with detection of helminth eggs and forming of detected objects gallery for viewing and dialogue classification. Ether-formalin precipitation together with PARASEP concentrator tubes and FE-5 workstation (DiaSys Corporation) specimen preparation is needed. For more details see MECOS-C2 introduces quality standard of faecal parasite analyses (pdf 1Mb)

The URINE SEDIMENT ANALYSIS (MECOS-USA^м) program for motorized complete set is integration of MECOS-VIM program for virtual slide production and special menus and blanks of standard urine sediment analysis. The program has embedded urine sediment atlas.

The SPERMATOZOA MOBILITY AND MORPHOLOGY ANALYSIS (MECOS-SMA^I) program for complete set with manual or motorized microscope:

processing of video with recording of microscope field of view during 2-10 sec under objective 20x phase contrast, above 0.4 M pixel&30 fps video resolution;

Dialogue choice of episode of best spermatozoa motion analysis;

Full number of spermatozoa measurement;

Spermatozoa mobility parameters measurements:

VAP - Average path velocity, mm/s;

VSL  - Straight-line velocity, mm/s;

VCL  - Curvilinear velocity, mm/s;

ALH  - Amplitude of lateral head displacement, mm;

BCF  - Beat-cross frequency;

STR  - Straightness VSL/VAP;

LIN  - Linearity VSL/VCL.

4 mobility type spermatozoa sorting (according WHO).

Morphology analysis of colored sperm: dialogue morphological sorting.

The BACTERIAL CLUMPS ANALYSIS (MECOS-BCA^I) program for macro viewing counts up automatically number of bacterial clumps in Petri dish. The technique works satisfactorily even clumps have different sizes and partially intersected. Every clump is marked by colored dot and user can control and correct result of counting.